Group publications

2015
  • B. Szulc, B. C. Sil, A. Ruiz and S. T. Hilton*, A Common Precursor Approach to Structurally Diverse Natural Products: The Synthesis of the Core Structure of (±)-Clausenamide and the Total Synthesis of (±)-Hyalodendrin, European Journal of Organic Chemistry, 2015, 34, 7438-7442. Access Article
  • A. Monaco, A. E. Aliev, and S. T. Hilton*, Intramolecular Acylal Cyclisation (IAC) as an Efficient Synthetic Strategy towards the Total Synthesis of Erythrina Alkaloid Derivatives, Chemistry a European Journal 2015, 21, 13909–13912.  Access Article
  • A. L. Tyson, S. T. Hilton*, L. C. Andreae, Rapid, simple and inexpensive production of custom 3D printed equipment for large-volume fluorescence microscopy, International Journal of Pharmaceutics 2015, 494, 651-656.   Access Abstract
  • L. V. Kerai, S. T. Hilton S. Murdan*, UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases, International Journal of Pharmaceutics 2015, 492, 177–190.Access Abstract
  • C.R.M. Asquith, M.L. Meli, L.S. Konstantinova, T.Laitinen, M.Peräkylä, A.Poso, O.A. Rakitin, K. Allenspach, R. Hofmann-Lehmann and S.T. Hilton*, Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the Feline Immunodeficiency Virus (FIV) as a model of HIV infection Bioorganic and Medicinal Chemistry Letters March 2015. 25, 1352-1355.Access Abstract
  • 2014
  • Asquith, C. R., Meli, M. L., Konstantinova, L. S., Laitinen, T., Peräkylä, M., Poso, A., . . . Hilton, S. T. (2014). Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection. Bioorg Med Chem Lett. doi:10.1016/j.bmcl.2014.04.073. Access Article
  • Patel, B., Saviolaki, G., Ayats, C., Garcia, M. A. E., Kapadia, T., & Hilton, S. T. (2014). Tuneable radical cyclisations: A tin-free approach towards tricyclic and spirocyclic heterocycles via a common precursor. RSC Advances, 4 (36), 18930-18932. doi:10.1039/c4ra02420f. Access Article
  • Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Poso, A., Rakitin, O. A., Allenspach, K., Hofmann-Lehmann, R., Hilton, S. T (2014). Viral Achilles heel: The nucleocapsid protein of FIV and related lentiviruses as a therapeutic target. ACS National Meeting, 248, MEDI 380. Access Abstract
  • Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Poso, A., Rakitin, O. A., Allenspach, K., Hofmann-Lehmann, R., Hilton, S. T (2014). Viral Achilles heel: The nucleocapsid protein of FIV and related lentiviruses as a therapeutic target. Tetrahedron Symposium, 15.
  • 2013
  • Sil, B. C., & Hilton, S. T. (2013). A mild and convenient base-catalysed approach to disubstituted epidithiodiketopiperazines. Synlett, 24 (19), 2563-2566. doi:10.1055/s-0033-1340161. Access Article
  • Sil, B. C., & Hilton, S. T. (2013). ETPs as anticancer agents: Synthesis and biological activity. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 246. Accesss Article
  • Mpima, S., Ohnmacht, S. A., Barletta, M., Husby, J., Pett, L. C., Gunaratnam, M., . . . Neidle, S. (2013). The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds. Bioorg Med Chem. doi:10.1016/j.bmc.2013.05.027. Access Article
  • Saviolaki, G., & Hilton, S. (2013). Tuneable radical cyclisations: Synthesis of biologically active heterocycles to target neuroinflammation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 246. Access Article
  • 2011
  • Sil, B. C., & Hilton, S. T. (2011). Diversity from simplicity: A common precursor approach towards natural products. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 241. Access Article
  • Sil, B. C., Cook, K. M., Schofield, C., Figg, W. D., & Hilton, S. T. (2011). Novel multi-component approaches towards dimeric epidithiodiketopiperazines as anti-cancer agents. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 241. Access Article
  • 2010
  • Hilton, S., Naud, S., Caldwell, J. J., Boxall, K., Burns, S., Anderson, V. E., . . . Oliver, A. W. (2010). Corrigendum to “Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2” [Bioorg. Med. Chem. 18 (2010) 707] (DOI:10.1016/j.bmc.2009.11.058). Bioorganic and Medicinal Chemistry, 18 (12), 4591. doi:10.1016/j.bmc.2010.05.014. Access Article
  • Mirizzi, D., Hilton, S. T., & Jones, K. (2010). Heteroaryl Radicals Review. ADVANCES IN HETEROCYLIC CHEMISTRY, VOL 100, 100, 101-143. doi:10.1016/S0065-2725(10)10004-X. Access Article
  • Hilton, S., Naud, S., Caldwell, J. J., Boxall, K., Burns, S., Anderson, V. E., . . . Collins, I. (2010). Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2 (vol 18, pg 707, 2010). BIOORGANIC & MEDICINAL CHEMISTRY, 18 (12), 4591. doi:10.1016/j.bmc.2010.05.014
  • Hilton, S., Naud, S., Caldwell, J. J., Boxall, K., Burns, S., Anderson, V. E., . . . Collins, I. (2010). Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2. Bioorg Med Chem, 18 (2), 707-718. doi:10.1016/j.bmc.2009.11.058. Access Article
  • 2009
  • Cook, K. M., Hilton, S. T., Mecinovic, J., Motherwell, W. B., Figg, W. D., & Schofield, C. J. (2009). Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1 alpha (HIF-1 alpha) and p300 by a Zinc Ejection Mechanism. J BIOL CHEM, 284 (39), 26831-26838. doi:10.1074/jbc.M109.009498. Access Article
  • Hilton, S. (2009). The hypoxia inducible factor-1 alpha and p300 interaction as a therapeutic target of the epidithiodiketopiperazine class of natural products. JOURNAL OF PHARMACY AND PHARMACOLOGY, 61, A152-A153.
  • 2008
  • Cook, K. M., Hilton, S. T., Schofield, C. J., & Figg, W. D. (2008). A promising cancer target: lead compounds blocking the HIF-1alpha/p300 interaction. Access Summary
  • Hilton, S. T., & Rossiter, S. (2008). Three Heterocyclic Rings Fused (5-6-5). In A. R. Katritzky, C. A. Ramsden, E. F. V. Scriven, R. J. K. Taylor (Eds.), Comprehensive Heterocyclic Chemistry III: A Review of the Literature 1995-2007 (pp. 711-772). Oxford, England: Elsevier Science.
  • Brown, R., Plumb, J., Ahearne, G. W., McDonald, E., Jones, K., & Hilton, S. T. (n.d.). Preparation of 2-[3H]-thiazol-2-ylidine-methylpyridine and related compounds and their use as antitumor agents.
  • 2007
  • Hilton, S. T., & Jones, K. (2007). The tandem radical route to indole alkaloids: An unusual rearrangement reaction. Arkivoc, 2007 (11), 120-128.
  • Hilton, S. T., & Jones, K. (2007). The tandem radical route to indole alkaloids: an unusual rearrangement reaction. Arkivoc, 2007 (XI), 120-128.
  • 2006
  • Aliev, A. E., Hilton, S. T., Motherwell, W. B., & Selwood, D. L. (2006). A concise approach to the epidithiodiketopiperazine (ETP) core. Tetrahedron Letters, 47 (14), 2387-2390. doi:10.1016/j.tetlet.2006.01.156
  • 2005
  • Hilton, S. T., Motherwell, W. B., Potier, P., Pradet, C., & Selwood, D. L. (2005). Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners. Bioorganic and Medicinal Chemistry Letters (15), 2239-2242.
  • 2004
  • Denison, S., & Hilton, S. T. (2004). A convenient synthesis of 2-cyano-3-substituted indoles. SYNLETT (15), 2806-2808.
  • Denison, S., & Hilton, S. T. (2004). A Convenient Synthesis of 2-Cyano-3-Substituted Indoles. Synlett, 2806-2808.
  • Hilton, S. T., Motherwell, W. B., & Selwood, D. L. (2004). An Expedient Entry into the a-Mercaptodiketopiperazine Nucleus. Synlett (14), 2609-2611.
  • 2001
  • Hilton, S. T., Ho, T. C. T., Pljevaljcic, G., Schulte, M., & Jones, K. (2001). A tandem radical approach to the ABCE-rings of the Aspidosperma and Strychnos alkaloids. Chemical Communications (2), 209-210.
  • 2000
  • Hilton, S. T., Ho, T. C., Pljevaljcic, G., & Jones, K. (2000). A new route to spirooxindoles. Org Lett, 2 (17), 2639-2641.
  • Hilton, S. T. (n.d.). A Mild and Convenient Base Catalysed Approach to Disubstituted Epidithiodikertopiperazines.