Alessandra Monaco

Dr Alessandra Monaco graduated from the University of Bologna in 2008 with a master’s degree in Medicinal Chemistry and Pharmaceutical Technology, which included 9 months placement at the Universidad Complutense de Madrid, in the group of Professor Josè Carlos Menendez. She obtained her PhD in 2013 under the supervision of Professor Leonardo Scapozza and Dr Yan Seimbille at the University of Geneva. Following this, again in the same institution, she collaborated with TRB-Chemedica as postdoctoral scientist. In 2013 she was awarded an Early Post-doc Mobility from Swiss national Foundation. She is currently SNF postdoctoral fellow in the group of Dr Stephen Hilton at the School of Pharmacy of the University College of London, working on the synthesis of CNS active alkaloids.

Current Research:

As postdoctoral fellow in the Hilton’s group, Dr Allessandra Monaco is exploring the potential of the intramolecular acylal cyclisation (IAC) to generate natural compounds such as erythratine and lycorine alkaloids derivatives. This synthetic approach is an ideal platform to establish research based on domino-iminium-cascade reactions following the IAC approach, for the synthesis of a wide array of both the natural products and a range of analogues with differing biological activities.

Publications:
  • Monaco A., Michelin O., Prior J., Rüegg C., Scapozza L., Seimbille Y. (2014) Synthesis of a Novel Non-Peptidic PET Tracer Designed for α5β1 Integrin Receptor. Journal of Labelled Compounds and Radiopharmaceuticals, 57, 365-370.
  • Monaco A. , Zoete V., Alghisi G. C. , Rüegg C. , Michelin O., Prior J., Scapozza L., Seimbille Y (2013). Synthesis and in Vitro Evaluation of a Novel [18F]FPPA-c[RGDfK] for αvβ3 Integrin Receptor Imaging. Bioorganic and Medicinal Chemistry Letters, 23, 6068-6072.
  • Bolognesi M. L., Ai Tran H. N., Staderini M., Monaco A., López-Cobeñas A., BongarzoneS., Biarnés X., López-Alvarado P., Cabezas N., Caramelli M., Carloni P., Menéndez J. C., Legname G. (2010). Discovery of a Class of Diketopiperazines as Antiprion Compounds. ChemMedChem, 5, 1324-1334.
Contact:

a.monaco@ucl.ac.uk